We present a new source of terminology for transnational data exchange in oncology, emphasizing the integration of both clinical and molecular data. In order to achieve best results in semantic interoperability, the ACGT project provides an ontology on cancer research and management. Besides examining pre-existing sources of terminology, we review methods of ontology development, and present best practices to be employed in the development of the ACGT Master Ontology. The clinical trial management system that is currently developed within ACGT constitutes a central use of the ontology at this point.
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