Influence of computer-based validation of Franz diffusion cell on the variation in drug release from topical dosage forms

摘要

Computer-aided software, Design of Experiment (DoE) was used to investigate the factors causing variation in drug release from topical dosage forms using Franz diffusion cells (FC). The use of DoE significantly reduced the number of validation experiments. Furthermore, DoE reveals factor interactions, which is not possible with the traditional one factor at a time (OFAT) approach.