Controlled Release Formulation of Sintered Wax Matrix Tablets For Ketorolac Tromethamine: Effect of Processing Methods And Sintering

摘要

Controlled release matrix tablets for Ketorolac tromethamine, water soluble drug, were formulated using Compritol 888 ATO as rate controlling hydrophobic wax. The matrices were prepared by various methods I.e. Direct compression/ dry blending, spray drying, partial melt granulation and melt granulation. The effect of sintering was studied and was compared with control unsintered tablets. The various evaluation parameters included percentage in-vitro drug dissolution profile, wettability (contact angle measurement), surface properties (SEM), DSC and FTIR studies. Sintering was found to significantly impact the drug release profile thus making it useful tool to achieve the desired drug release.