The development of multifunctional nanocomplexs for drug delivery in oral cancer therapy

摘要

Oral cancer has been denoted as the sixth most common cancer in the world. Chemotherapy is one of the major therapeutics for advanced oral cancer cases. Advances in drug delivery system draw a niche for cancer treatment due to improved local therapeutic concentration, side effect control and pharmacokinetic profile. A novel drug delivery system made of superparamagnetic iron oxide nanoparticles (SPIONs) covalently linked with alginate was developed for oral cancer therapy. The results suggest that Fe_3O_4@Ca-alginate nanoparticles could effectively release doxorubicin in a spatial-temporal controlled manner and even achieved higher release rate in cancer intracellular compartments. These data suggest that Fe_3O_4@Ca-alginate could be a potential candidate of advanced drug delivery systems for advanced cancer therapy.