Simultaneous and Individual Determination of Six Redox-Active Biomolecules Using a Modified Graphite Paste Electrode with Immobilized Ferric Cyanide-Chitosan Polymer Ion Pair on the Multi-Walled Carbon Nanotubes

摘要

Redox-active biomolecules such as Ascorbic acid (AA), Dopamine (DA), Uric acid (UA), Tryptophan (Trp), Xanthine (XA), and Caffeine (CA) are all critical for biological homeostatic maintenance. The depletion or over consumption in any of the biomolecules can lead to detrimental effects. For example, previous reports have suggested the depletion of dopamine in the brain is highly correlated to the progression of Parkinson's disease. Caffeine, though not a bio-molecules, it is frequently consumed, and overdose can lead to neurological damage, or even death. In extension, these biomolecules tend to exists as a mixture. Thus, it becomes important to develop a platform that enables the monitoring of these biomolecule concentrations simultaneously.