(Keynote) Biosensor and Bioreactor Performance of a Chemically Modified Electrodynamic Microfluidic Channel

摘要

Numerous biological sensing devices have been developed for medical and health care purposes, to date. However, many cases demand a simple, inexpensive, and efficient device, concurrently performing the reaction, separation, and detection. Hence, we have established the separation detection method of molecules and nanoparticles using a symmetrical AC electric field applied electrochemical microfluidic device fabricated with a screen printing technique (EMC). The separation principle was also evaluated with the lateral movement of targets perpendicularly against the channel walls under the AC field, which was analyzed by simulation using the mathematically derived equation from Newtonian fluid mechanics. The device can be used for various reactions and detections of complex biological species in the channel. Here, some applications will be introduced; 1) separation detection of cancer cells, 2) simultaneous analysis of glycated hemoglobin family, and 3) aptamer generation, separation, and biosensor fabrication.