Future studies of the role of immune status in regeneration of skin covering of space missions crewmembers

摘要

The members of long space missions quite often suffer from the damage of skin covering which affects quality of their life and performance. Abnormal immune responses observed in microgravity may pose serious consequences, especially for long-term space missions to Moon and Mars. The immune mechanisms of regeneration of skin lost during diseases and injuries of various etiologies, that are important for space medicine, are still understudied, which will complicate treatment, especially in case of abnormal dynamics of wound healing. In order to develop a wound healing strategy in the conditions of during interplanetary missions, it is necessary to identify trigger immune mechanisms involved in the regeneration of the skin covering. The conducted studies allowed to state that changes in the immune system can be one of the most important factors determining the results of such processes as inflammation, regeneration, proliferation, and play an important role in the duration of healing, and resistance to treatment. The obtained results serve as a basis for continuing study of the role of the immune system in skin regeneration under space flight conditions.