The Effect of Poly (Aspartic Acid-co-Lactic Acid) Nanospheres on the Lung Metastasis of B16-BL6 Melanoma Cells by Intravenous Administration

摘要

Poly (aspartic acid-co-lactic acid) (PAL) [1] has been investigated as a new biodegradable material for Drug Delivery Systems (DDS) for some time. Similar to the poly (lactic acid-co-glycolic acid) (PLGA) nanospheres, the PAL nanospheres [2] can controlled-release encapsulated drugs by hydrolysis and adhere to the mucous membranes to improve the drug absorption. In this study, the vitamins encapsulated PAL nanospheres were applied on mice to examine their effect on tumor metastasis and safety as an injectable DDS material for anti-cancer and other drugs. The mouse melanoma B16BL6 cells have shown a great tendency of metastasizing to the lungs via the tail vein in a model that created experimental lung metastatic tumors. This experiment investigated the effects of PAL nanospheres on the tumor metastasis, when being administered with mouse melanoma B16BL6 cells. The experimental results suggested that PAL nanospheres administered intravenously were highly safe and did not promote the metastasis of melanoma cells to the lungs.