Role of Microwave Radiation on Radiopharmaceuticals Preparations

摘要

Advantages of the MW-irradiation in comparison with classical heating methods are confirmed in all studies here reported. In radiochemistry microwave heating showed itself very useful to solve several problems specific of this field. In addition to the well known effect of shortening the time interval to complete a reaction, MW-irradiation enables a less aggressive treatment of the reagents, extremely important when unstable molecules must be labelled and a high purity of the product is requested. The introduction of MW treatment proved to be the right way to obtain labelled rifamicine, otherwise only unsatisfactorily results were obtained. The theoretical attempts to explain these various effects take into account a non thermal effects of MW, since some of our experimental data cannot be explained, till now, by thermal activation.