The study of spectral changes in THz range in normal and pathological skin in vivo depending on the dehydration methods used

摘要

The terahertz (THz) attenuated total reflectance (ATR) imaging of normal and pathological skin under the action of various dehydration agents was carried out in vivo. Studies were conducted on animal models (the mouse), patients with diabetes, and healthy volunteers. For measurements, each animal was leaned against the ATR prism of the skin surface, and several locations in the skin of each animal were analyzed. Places on the skin for analysis were chosen so that the intensity spectra of the THz signal were practically the same for selected points. THz spectra measurements were carried out every 10 minutes within 45 minutes interval under the action of a dehydration agent. 40% glucose was shown to provide the most effective improving tissue optical clearing effect in the THz range.