Hybrid composites based on alumina and magnetite nanoparticles for biomedical application

摘要

Porous nanostrucutred finds a great number of applications in science and industry. One of the most promising area of application of such materials lies in the field of drug delivery and creation of targetable nanoformulations. Here we describe a convenient and scalable method of production of magnetic porous matrices for drug delivery. The materials were created of stable boehmite and magnetite hydrosols via room-temperature sol-gel transition. As the result mesoporous hybrid matrices were produced with their textural and magnetic properties dependent on the ratio of components in their composition. The materials showed excellent biocompatibility on HeLa cell line in concentrations up to 200 μg/mL and good loading capacity with a model drug doxorubicin.