Preparation and Pharmacokinetics of Candesartan Cilexetil with Polymer Materials in Self-Microemulsifying Drug Delivery Systems

摘要

The candesartan cilexetil SMEDDS with PEG-PLA as long-circulating materials were successfully prepared and characterized by appearance, size and size distribution, morphology of emulsion and stability. The emulsion showed a narrow size distribution, well-proportioned in good agreement with polydispersity index of 0.005 and 3.6 nm diameter. The candesartan cilexetil SMEDDS were precipitated for 30 days at 25 °C or 37 °C. Meanwhile, Pharmacokinetics experiments illuminated that the candesartan cilexetil SMEDDS in rats had a larger drug curve concentration (AUC) compared to the tablets in the experiments.