Experimental and Theoretical Studies on Regiodivergent C-HAlkylation of Quinolines with Alkenes by Half-Sandwich Rare-EarthCatalysts

摘要

Quinoline is an important structural motif in pharmaceuticals,agrochemicals,and naturalproducts.The development of selective and efficient protocols for the synthesis of quinolinecontainingcompounds is therefore of great interest and importance.Among possibleapproaches,catalytic C-H addition to alkenes is the most atom-efficient route for the synthesisof alkylated quinoline derivatives.However,major efforts have been donated to the C-H bondalkylation of quinolines on the more reactive N-heterocyclic ring,while a selective C-Halkylation of quinolines on the carbocyclic ring remains largely underdeveloped.1