Morphofunctional Changes in the Kidneys Affected by Increased Concentration of Molybdenum in the Environment

摘要

The morphological and physiological state of the kidneys in experimental rats treated with molybdenum in the amounts of 0.0255 mg/kg, 0.425 mg/kg and 1.125 mg/kg was studied. Experiments were conducted on white laboratory rats of the Wistar line. The studies were conducted using histological, polarographic and mathematical methods. Sample molybdate sodium was prepared expressed metal. The experiment was carried out for 30 days. Histological examination of sections revealed significant pathological changes in the renal parenchyma. In the glomeruli of the cortical layer of experimental animals of the second series, anemia was observed: the capillaries are empty, they do not contain red blood cells. The tubular lumens are dilated, edemas; lymphostasis were observed in the stroma of the pyramids, and there was pronounced stagnation of blood in the direct veins. In epithelial cells, small-drop fat degeneration was observed. High concentrations of molybdenum causes hypertrophy of the kidneys, compaction of the vascular glomerulus, expansion of the cavity of capsules, narrowing of the proximal nephrons, poor circulation. A tenfold increase in dose causes the necrosis of the nuclei of endothelium and mesanglia, foci of necrosis, multiple point hemorrhages.