Selective damages of tumor vessels by 1060 nm pulsed irradiation

摘要

The preferential absorption of photon energy by hemoglobin, oxyhemoglobin and water at specific wavelengths (400 nm, 560-580 nm, 800-980 nm, 1064 nm) allows the use of laser radiation for the treatment of tumors and vascular lesions. Absorption of light energy by oxyhemoglobin at a wavelength of 1060 nm creates thermal energy, allowing to selectively damaged blood vessels with minimal damage to surrounding tissues. In this paper, were developed laser irradiation regimes to selective damage the tumor vessels using a semiconductor laser ?Lakhta-Milon? at wavelength of 1060 nm with maximum power 20 W and pulse duration 10-50 ms. The calculations were based on the threshold for thermal vessels damage with various vessels sizes: less 8 μm, 10-30 μm, over 30-100 μm. Histological studies of carcinoid tumor after irradiation revealed that thermal damage of tumor vessels may be localized under pulsed irradiation without causing thermal tissue necrosis. The pulse irradiation modes developed in this work have potential applications in the method of laser airways recanalization for tumoral stenosis in therapeutic bronchoscopy.