Simulations to Evaluate the Impact of Ca~(2+) release from Endoplasmic Reticulum on Intracellular Ca~(2+) Oscillations

摘要

The role of Ca~(2+) release from endoplasmic reticulum (ER) in influencing intracellular Ca~(2+) oscillation is elucidated. Various types of oscillations in a two-pool model are discussed, based on fast-slow dynamic analysis. Three types of burster are obtained by varying the parameter affecting Ca~(2+) release from ER, namely, subHopf-subHopf of point-cycle type, subHopf-cycle of point-cycle type with multiple rhythms and fold-fold of point-point type. The results may help us better understand the role of Ca~(2+) release played in complex intra- and inter-cellular Ca~(2+) signaling.