Synthetic Study for Antibiotic Cyclodepsipeptide Piperidamycins

摘要

Piperidamycin F (1) was isolated from mutant strains of a soil-isolated Streptomyces sp. by Hosaka et al. in 2009, and are known to exhibit potent antibacterial activity. In addition, 1 possesses a unique and unusual tetrapiperazic acid moiety in the 18-membered cyclodepsipeptide scaffold,1 thus this natural product would be a good candidate in the development of a novel antibacterial drug.