Pictet-Spengler-type Reactions using Metal Cation-Exchanged Montmorillonite in Water

摘要

The Pictet-Spengler reaction with excellent functional group tolerance provides one of the most important strategies for carbon–carbon bond formation in synthetic organic chemistry. This synthetic methodology can be applied for the construction of ubiquitous nitrogen-containing compounds that are biologically active, such as tetrahydroisoquinoline, β-carboline derivatives, and indoles. Tryptamine with electron-donating group is often used in the Pictet-Spengler reaction, while non-substituted indole has lower reactivity and thus stoichiometric amounts of strong acids are required.