Direct Catalytic Alcoholysis of Unactivated 8-Aminoquinoline Amides

摘要

Amides are ubiquitous functionalities and important structural motifs in organic molecules due to their high stability, and they have recently been used as reliable directing groups for regioselective functionalization reactions.1 Enhancing the utility of these functionalization reactions, selective transformation of the directing group amides into more useful carbonyl groups, such as esters, is an important issue. In most cases, however, cleavage of C-N bond of 8-aminoquinoline amides requires harsh reaction conditions2, 3, which limit the functional group compatibility.