Methoxylation of Aroyl Fluorides with Cyclopentyl Methyl Ether Mediated by Tetrabutylammonium difluorotriphenylsilicate (TBAT)

摘要

The inert bond activation is very useful strategy in modern organic synthesis. The cleavage of carbon-oxygen and carbon-fluorine bond is quite challenging.[1] Many elegant strategies have been developed for C(sp~3)-O bond activation, but these protocols still suffered from being highly dependent on pincer-ligated metal complex, substrates limited to aryl ethers containing a fused aromatic ring or highly nucleophilic triarylphosphines as well as orthodirecting groups.