In vivo kinetics of functionalized albumin in mouse

摘要

Research on biodistribution of N-glycan modified albumin in mice has been advanced in our laboratory. In previous reports, we mostly investigated the binding properties of heterogenous glycoconjugates in cell-based experiment. However, pattern recognition of heterogenous glycan modified-albumin in vivo has not been extensively explored. In this work, we investigated the in vivo kinetics of heterogenous glycoconjugates by a whole-body fluorescence imaging. The key is to use albumin as an in vivo stable template to clusterize various glycans for multivalency effects.