Gold(I)-Catalyzed Construction of Nitrogen-Containing Medium-Sized Ring Systems by Cycloisomerization and Azaspirocyclic System by Dearomatization

摘要

Gold complexes can increase the electrophilicity of alkynes by coordination and facilitate smooth nucleophilic addition to make a new bond. In general, the reaction of enyne-containing substrates with gold catalysts, called cycloisomerization, is well-developed because it gives a cyclic structure by C-C bond formation in high atom efficiency under mild conditions.