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Development of global DNA methylation level detection system using MBD-luciferase and CXXC-luciferase

机译：使用MBD-荧光素酶和CXXC-荧光素酶的全局DNA甲基化水平检测系统的研制

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摘要

In cancer cells, the transposable elements that constitute approximately 45% of genomic DNA are hypomethylated. Therefore, the global DNA methylation level can be used as biomarkers for cancer diagnostics.

机译：在癌细胞中，构成大约45％的基因组DNA的可转换元件是如下甲基化的。因此，全局DNA甲基化水平可用作癌症诊断的生物标志物。

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《日本化学会春季年会講演予稿集》|2018年|1 CD-ROM|共1页
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作者
Yuji Baba; Isao Karube; Wataru Yoshida;
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中图分类石油化学工业;
关键词
DNA methylation level; Bioluminescence resonance energy transfer; Methyl-CpG-binding domain; CpG-binding domain; Luciferase;

机译：DNA甲基化水平;生物发光谐振能量转移;甲基CpG结合结构域;CPG结合域;荧光素酶;

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2. DNA Methylation Possible Adjunct to Screening for Neurodevelopmental Syndromes: DNA methylation signatures were identified for several neurodevelopmental Mendelian disorders, and hold promise as a supplement to standard procedures for screening and detection of these diseases [J] . American journal of medical genetics, Part A . 2018,第4期

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4. Development of global DNA methylation level detection system using MBD-luciferase and CXXC-luciferase [C] . Yuji Baba, Isao Karube, Wataru Yoshida 日本化学会春季年会講演予稿集 . 2018

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7. Simultaneous Determination of Global DNA Methylation and Hydroxymethylation Levels by Hydrophilic Interaction Liquid Chromatography–Tandem Mass Spectrometry [O] . Liangtao Zhang, Lijian Zhang, Keyuan Zhou, 2012

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Development of global DNA methylation level detection system using MBD-luciferase and CXXC-luciferase

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