Development of the Stereoselective Oxidation System Catalyzed by Cytochrome P450BM3 Using Decoy Molecules

摘要

The cytochrome P450 family is a superfamily of heme-containing enzymes which catalyze direct hydroxylation of a C?H bond in organic compounds. P450BM3 from Bacillus megaterium is an attractive candidate for industrial applications due to its outstanding hydroxylation activity;; the reaction rate for fatty acids, native substrates of P450BM3, reaches 103 -104 min-1 .