Helically Chiral Nucleophilic Polymer Catalyst for Asymmetric Acyl Rearrangement of Oxindole Derivatives

摘要

We have established helically chiral polymer catalysts, which show high enantioselectivities derived from single-handed helical structure of poly(quinoxaline-2,3-diyl)s (PQX). Introduction of achiral 4-(dialkylamino)pyrid-3-yl pendants onto the helically chiral PQX scaffold led us to find highly enantioselective nucleophilic catalyst in asymmetric Steglich rearrangement of azlactone derivatives. we herein report on asymmetric acyl rearrangement of oxindole derivatives in the presence of the PQX-based nucleophilic catalysts.