PHARMACODYNAMIC AND PHARMACOKINETIC PROPERTIES OF INSULIN ASPART FOLLOWING SUBCUTANEOUS AND INTRAMUSCULAR INJECTION IN CATS

摘要

Insulin aspart (Aspart) is a rapid-acting insulin analog that has been shown to be an effective treatment for diabetic ketoacidosis (DKA) when administered by intermittent subcutaneous (SC) injection in humans. In cats, rapid-acting insulin analogs have not yet been evaluated, and the most commonly used protocols for DKA involve delivery of regular insulin via constant intravenous infusion, which can be technically challenging. The aim of this study was to determine the pharmacodynamics (PD) and pharmacokinetics (PK) of Aspart following SC and intramuscular (IM) injections in healthy cats.