MicroRNAs have been identified as sensitive, non-invasive diagnostic markers for early detection of human malignancies. To date there have been very few studies of microRNA expression in the serum of domestic animals with no known analysis of the microRNA present in mature erythrocytes. Feline erythrocytes are known to be sensitive to oxidative damage and we are interested in their potential use as a model for the study of systemic oxidative stress. Identification of specific microRNA which are dysregulated under these conditions may be sensitive biomarkers of oxidative stress.
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