BONE MARROW TRANSPLANTATION AND EPIGENETIC MODULATION OF HEMATOPOIETIC PRECURSORS IN EQUINE COMMON VARIABLE IMMUNODEFICIENCY

摘要

Our laboratory studies common variable immunodeficiency (CVID) in horses, a rare and fatal condition that manifests with late-onset impaired B cell production in the bone marrow (BM) and, consequently, hypogammaglobulinemia. Our studies have shown that the B cell production is halted at the pre-pro B cell developmental transition due to epigenetic aberration of essential lineage-specific transcription factor regulatory regions, with resulting gene silencing of PAX5.