Evaluation of fucoidan bioactivity as anti gastric ulcers in mice

摘要

Fucoidan is a polysaccharide compounds containing sulfate group. Fucoidan is found in brown seaweed. In this study, we assess fucoidan activity extracted from brown seaweed Sargassum crassifolium origin from Binuangeun, Banten. Fucoidan extract was tested in mice in vivo. Observations were carried out during 16 days the control (without fucoidan) and fucoidan treatment. Fucoidan were given in various concentration of 100, 200, 300, 400 ppm. On the 14th day, aspirin was given to mice with pre-treated fucoidan 400 ppm as gastric ulcer induction. The fucoidan extracts compositions showed: water content 3.11%, uronic acid 556 ppm, 0.12 ppm sulfate and 1648 ppm total carbohydrate. Results from histopathology assay in mice tissue stomach showed that 100 ppm of fucoidan can inhibit gastric ulcers caused by 400 ppm aspirin irritation. Fucoidan was associated with an increase in the mucus layer in the gastric mucosa.