Application of Biomarkers in Individualised Medicine: Syn-mRNAs as Vaccination Tools in Tumor Therapy

摘要

Individual tumors display invidual biomarker profiles which can be exploited as highly specific vaccination targets for efficient immune response against the individual tumor tissue of the individual patient. The mRNA-based approach was already introduced more than 10 years ago [1]. Initially, it relied on the preparation of total mRNAs from tumor tissues. This approach has several obvious disadvantages: the composition of these mRNA preparations is not well defined, the amount of critically important mRNA species may be too low, and self-antigens in the mRNA pool may trigger autoimmunity.