Data Deluge: Challenges and Solutions for Implementing a Precision Medicine Approach to Create the TRACK-TBI Information Commons

摘要

The Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) initiative is an international multicenter, multidisciplinary clinical study funded by the NIH, DoD, private and industry partners. The TRACK-TBI investigators are using precision medicine approaches to create a comprehensive TBI Information Commons that integrates clinical, neuroimaging, proteomic, genomic, and outcome biomarkers in the effort to improve TBI classification and to identify new diagnostic and prognostic markers for future clinical treatment trials. Teams at 19 trauma centers have enrolled nearly 3000 TBI subjects across the injury spectrum from concussion to coma within the first 24-hours following injury. Subjects are followed during their acute care phase and at four follow-up visits over 12 months. Clinical and outcomes core data are collected in a web-based electronic case report form that has over 200 forms and 15,000 data fields.