Cigarette smoking is one of the significant risk factors for premature death and it seems influence to nearly six million human lives per year throughout the world (Warren et al. 2008). Twin studies of the smoking habit showed a contribution of the genetic factors to be became the regular smokers (Carmelli et al. 1992; Hughes 1986). So far, there are 7 genome-wide association studies in GWAs catalogue (https://www.ebi.ac.uk/gwas/ home), and 47 SNPs have been reported as the genetic risk variants for the smoking behavior. In this study, we tested the 47 SNPs in a large Korean cohorts (Ansan-Ansung cohorts of Korea Genome Epidemiology cohorts), specifically in male subjects (Nonsmoker = 420 and smoker = 973).
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