A Mathematically Informed Approach to Optimizing Intratumoral Delivery of Oncolytic Viruses Using Hemodynamic Alterations

摘要

Oncolytic virotherapies like vesicular stomatitis virus (VSV) are experimental cancer therapies in which naturally evolved or engineered viruses selectively infect tumor cells resulting in virus-induced tumor cell death (oncolysis), immunotherapeutic responses, and tumor regression. Our mathematical model predicts the probability of achieving tumor cure from direct oncolysis is dependent on the amount and distribution of intratumoral infection, with an increase in delivery, distribution, and size of intratumoral infectious centers resulting in a higher probability of tumor cure.