CTEN: A Novel Target of DeltaNp63alpha and a Promising Biomarker for Prostate Cancer

摘要

p63, a transcription factor of p53 family, is a linchpin of epithelial development and homeostasis. p63 drives many target genes involved in cell survival, adhesion, migration and cancer. In this study, we identified CTEN as a downstream target of deltaNp63alpha, the predominant p63 isoform. CTEN and deltaNp63alpha are both highly expressed in normal prostate basal cells and down-regulated in prostate cancer. Sliencing of deltaNp63alpha results in decreased mRNA and protein levels of CTEN.