Disruption of Cell-Cell Contact-mediated Notch Signaling via Hydrogel Encapsulation Reduces Mesenchymal Stem Cell Chondrogenic Potential

摘要

Herein we showed that hydrogel encapsulation and failure to form cell-cell interactions and activate Notch signaling significantly reduces MSC chondrogenesis (Fig. 1D). With an improved understanding of cell-cell interactions and cell function, more effective biomaterials-based tissue regenerative strategies can be realized through synergistic application of biophysical and biochemical signals that emulate both the cell microenvironment and cell-cell interactions.