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Fiber Reinforced Collagen-GAG Scaffolds for Tendon Bone Junction Repair

机译:用于肌腱骨交界部修复的纤维增强胶原胶质支架

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We have demonstrated the ability to enhance the mechanical properties of CG biomaterials through ABS fiber-reinforcement. By varying the geometry of the fiber-reinforcements, we can tailor the mechanical properties of our overall construct. We have also demonstrated the ability to immobilize PDGF to enhance cellular proliferation. In the future, fiber reinforcements can be created from poly(lactic acid) (PLA), which has enhanced bioactivity but similar mechanical properties compared to ABS. Fiber reinforcements can be functionalized with a variety of growth factors in order to elicit a range of responses.
机译:我们已经证明了通过ABS纤维增强来增强CG生物材料的机械性能的能力。通过改变纤维增强材料的几何形状,我们可以根据我们的整体构建体定制机械性能。我们还表明了固定PDGF以增强细胞增殖的能力。将来,可以从聚(乳酸)(PLA)产生纤维增强剂,其具有增强的生物活性,而且与ABS相比具有相似的机械性能。纤维增强材料可以用各种生长因子官能化,以引发一系列反应。

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