Nanoparticle Mediated Delivery of Glutamate Enhancers to Restrain Autoimmune Reactions

摘要

The findings above demonstrate a low energy method for synthesizing PHCCC loaded particles that reduce inflammatory cytokine secretion, DC activation, and T cell proliferation without toxicity. These ex vivo studies support a platform that could provide similar effects in vivo to help combat autoimmune diseases by restraining inflammation. Importantly, future studies will assess the phenotype of T cells to quantify any shift in function away from inflammatory phenotypes (e.g., T_H17) and toward regulatory populations (e.g., T_(REGS)). This approach could ultimately contribute to therapies that selectively suppress inflammatory reactions without broad immunosuppression hindering current treatments for autoimmune disease.