Cardioprotective Effects of Aqueous Extract of Salvia miltiorrhiza on Heart Failure is Reiated to SDF-1/CXCR4 Axis and Bcl-2 Family Expressions

摘要

Salvia Miltiorrhizae Bge, a popular Chinese herb has been widely adopted for use in Chinese hospitals for both the prevention and the active management of cardiovascular disease, there is no study on its cardioprotective effects against HF and more importantly, the underlying mechanisms of its beneficial effects by SDF-1/CXCR4 axis remain poorly understood. This study was performed to investigate the protective effects and possible mechanism of aqueous extract of Salvia miltiorrhiza (AESM) on HF rats. In the study, cardioprotective effects of AESM on HF rats was evaluated by herat function, myocardial pathology, myocardial cell proliferation, SDF-1, CXCR4 and Bcl-2 family mRNA expressions. In the experiment, we found that AESM exerted beneficially protective effects on the HF rats, mainly recoverying normal heart function, myocardial pathology and myocardial cell proliferation. The underlying mechanism of these protective effects of AESM appeared to involve improving the SDF-1/CXCR4 axis and Bcl-2 family expressions.