Transcranial sonography for the diagnosisof Parkinson's disease

摘要

Parkinson's disease is a progressive neurological disorder, which results from thedegeneration of dopamine-producing cells in the substantia nigra (SN). Clinicalsymptoms typically include static tremor, bradykinesia, myotonia, and posturalinstability. However, clinical features in the early stages of Parkinson's diseaseare atypical. Therefore, it is important to develop a diagnostic tool aimed torecognize the early stages of Parkinson's disease. Transcranial sonography as anoninvasive technology has become an important instrument in the diagnosis ofParkinson's disease and in the differential diagnosis of Parkinsonism. Above all,transcranial sonography has the capability of detecting substantia nigrahyperechogenicity, which is key to catching Parkinson's disease in its earlystages. The main purpose of the current paper is to summarize the significance oftranscranial sonography in the diagnosis and differential diagnosis of Parkinson'sdisease.