ADAPTATION OF MICE MUSCLE PROPERTIES IN HYPO/HYPERGRAVITY ENVIRONMENT

摘要

To understand how gravity determines muscle function in mammals, we focused our study on the influence of micro and hypergravity (HG) environment on the morphological, biochemical and contractile properties of an antigravitational mice soleus muscle. The study has been conducted on adult C57Bl6J male mice, divided into 3 groups: control (1G), microgravity (0G) and hypergravity (2, 3 and 4G) groups. A decrease in muscle wet weight/body weight was observed in 0G muscles, whereas HG induced an increase in this parameter only at 3 and 4G. The 0G muscle evolved towards a faster type (neo-expression of myosin IIX, while 3G muscles presented a slower phenotype. The results were assessed by contractile behaviour.