Controlled Loading and Releasing of Meloxicam by ?-Cyclodextrin Polymeric Networks

摘要

Cyclodextrins (CDs) are well known cyclic oligosaccharides with the ability of forming complexes with hydrophobic guests being of suitable size. The most common pharmaceutical applications of CD and their chemical derivatives are to improve the aqueous solubility of the complexed species. Meloxicam is a nonsteroidal anti-inflammatory drug used to relieve the symptoms of arthritis, primary dysmenorrhea, fever, and as an analgesic, especially where there is an inflammatory component. Meloxicam is hard to dissolve in water, whose solubility depends on pH. With the help of CD, the solubility of Meloxicam will be increased significantly [1]. The inclusive association between CD and guest graft in poly(acrylic acid) (PAA) has been used to construct polymeric networks [2-5]. In this paper, the loading of Meloxicam by β-CD and its inclusive polymer networks, as well as the releasing of drugs by degradation of CD using amylase (Figure 1) were investigated by means of UV spectrum and rheology.