Preparation, Characterization and Antibacterial Activity of Amoxicillin-loaded Laponite/Poly(lactic-co-glycolic acid) Composite Nanofibers

摘要

Electrospun hybrid nanofibers have been used to encapsulate drugs for sustained release with improved release profiles 1, 2. The existence of multiple components within the hybrid nanofibers enables the fibers with distinctive features such as flexibility in surface functionalities, superior mechanical durability, and interconnected and readily controlled secondary structures 3, 4. Therefore, hybrid nanofibers have generated great interest in drug delivery systems. As a synthetic clay material, laponite (LAP) has been used as a drug carrier because the interlayer space of LAP can be used for effective drug encapsulation with high retention capacity 5, 6. In this present study, LAP nanodisks were first used to encapsulate a model drug of amoxicillin (AMX). Then, the LAP/AMX nanodisks were incorporated within PLGA nanofibers via electrospinning to form PLGA/LAP/AMX nanofibers. We anticipate that incorporated AMX should first come out from the reservoir of LAP, and then from the polymer matrix, therefore, the PLGA/LAP-based drug delivery system can better control the drug release rate and allow the drug to exert long-term therapeutic effect.