Comparison of WI-38 and NIH/3T3 Cells As Standards for the Evaluation of the Inhibition of Pancreatic Cancer Cell Lines by Organotin Polymers Derived From Drugs Without Aromaticity- Thiodiglycolic Acid, Chelidonic Acid, and Isomannide

摘要

INTRODUCTION We recently evaluated a number of different organotin polymers for their ability to inhibit two pancreatic cancer lines based on WI-38 and NIH/3T3 cell results. At times there is a difference in the ability to inhibit cell growth between materials that contain aromatic portions and those that lack these aromatic moieties. The present report describes results for polymers derived from three drugs that do not contain aromatic moieties within them.