FISH WOULD EAT FISH - PHYTOGENIC ALTERNATIVES FOR ANTI-INFLAMMATORYI EFFECTS INFEED FORMULATION

摘要

Antiinflammatory effects of food components are currently a topic of great interest in livestock nutrition. Key substances to reduce intestinal inflammation are feeds high in polyunsaturated fatty acids (PUFA) such as fish oil. Traditional fish dietswere high in fish oils and therefore had strong anti-inflammatory properties. With current trends to make fish farming more sustainable, by using less ingredients derived from fisheries, alternative additives have to be found which can provide the anti-inflammatory effects required to ensure a healthy and functional intestinal/gut mucosa. This situation is aggravated by the ability of certain legumes, particularly soy bean, to induce enteritis in fish Sahlmann, et al., (2012). Recent trials have focusedon land-based livestock Gessner, et al. (2011), but NF- kB, the master regulator of inflammation, is preserved with similar functions across all vertebrate species and has been shown to be a key element in inflammation mediation in pylogenetically distant fish species (Sahlmann, et al., 2012; Zang, et al., 2012). A positive effect downregulating the NF- kB response in mammals might therefore have a similar beneficial effect in fish as well. Therefore the objective of this study was to investigate the potential of selected flavonoids which have shown significant anti-inflammatory effects in in-vitro trials.