A NOVEL ORAL COLON-TARGETING DRUG DELIVERY SYSTEM BASED ON RESISTANT STARCH ACETATE

摘要

Novel oral colon-targeting film-coated pellets based on resistant starch acetate (RSA) film were prepared and the effect of plasticizer content, film coating thickness, drug load and drug molecular weight on drug release was investigated. Desired colon-targeting and drug release properties can easily be obtained by adjusting the coating thickness as well as the plasticizer content of the RSA film. This suggested that RSA film coated-pellet is an excellent and potential oral colon targeting drug delivery system.