Synthesis and Dual Fluorescence Property of Novel Dihydroxy Phosphorus Tetrabenzotriazacorrole Derivates

摘要

Photodynamic diagnosis (PDD) is of increasing interest for diagnosis in oncology. It is based on the selective accumulation of photosensitizers in tumours, such as porphyrin and phthalocyanine. In the present study, novel dihydroxy phosphorus tetrabenzotriazacorrole derivates have been synthesized. And photophysical properties of these derivates have been studied. Dihydroxy phosphorus tetrabenzotriazacorrole derivates display a fluorescence which is from the higher S_2 electronic state. With excitation at 614 nm, the fluorescence maximum is at 668 nm for dihydroxy phosphorus(V)-2,9,16,23-tetranitrotetrabenzotriazacorrole {P(OH)_2TBC(NO_2)_4} in N, N-dimethylformamide (DMF). But with excitation at 310 nm for P(OH)_2TBC(NO_2)_4 in DMF, in addition to S_1 fluorescence a new fluorescence peak appears at 490 nm, which is attributed to S_2-state fluorescence. It indicates that the dihydroxy phosphorus tetrabenzotriazacorrole derivates might have a potential application as a dual fluorescent marker for photodynamic diagnosis.