Towards Accurate and Label-free Monitoring of Bio-analytes using Supercontinuum based Multispectral Photoacoustic Spectroscopy in the Extended Near-infrared Wavelength regime

摘要

In this work, we report a cost-effective supercontinuum (SC) laser-based multispectral photoacousticspectroscopy (MSPAS) system for studying spectral characteristics of various analytes. Wedemonstrate an in vitro label-free monitoring of the analytes in the extended near-infrared (NIR)(1540–1840 nm) spectral range. We further demonstrate how a simple ratiometric analysis inconjunction with linear regression can be used for accurate prediction of glucose over commonlyencountered physiological levels inside the human body (0–400 mg/dL). Looking forward, theproposed SC-based MSPAS system provides a framework for the development of label-free andnon-invasive monitoring multiple bio-analytes accurately, with potential translation to clinical invivo applications.