LIPSS Formation of Chitosan/hydroxyapatite Composites via Femtosecond Laser Processing for Bone Tissue Engineering Applications

摘要

The combination of chitosan (Ch) and hydroxyapatite (HAp) materials for creation of biomimetic matrices suitable for 3D support in tissue engineering is widely used due to its components' good biocompatibility and non-toxic characteristics. In this paper, we present preliminary experimental results on synthesizing Ch/HAp thin composite films and irradiating them by femtosecond laser pulses with the purpose of surface modification. For a Ch/HAp composite scaffold, we established the development of laser-induced surface periodic structures (LIPSS) at λ = 800 nm, τ= 130 fs, laser fluence F = 2.079 J/cm~2 and number of applied laser pulses N = 10 via observation by scanning electron microscopy and confocal microscopy.