2-benzhydrylsulfinyl-N-hydroxyacetamide Extracted from Fig: A good Therapeutic Agent against Staphylococcus Aureus

摘要

2-benzhydrylsuIfinyl-N-hydroxyacetamide was extracted from fig fruit. The fig fruits were placed in selective sequentially extract processes using soxhlet. The antibacterial activity of 2-benzhydrylsulfinyl-n-hydroxyacetamide was tested against human pathogenic Staphylococcus aureus using the Optical density assy technique to measure bacterial growth curve. The alternation in the cluster shap of treated S. aureus was measured using SEM technique. The mechanism by which 2-benzhydrylsulfinyl-N-hydroxyacetamide destroy bacterial strain was measured by investigation of reactive oxygen species (ROS) using Acridine orange-ethidium bromide (AO/EtBr) double staining assay. The results of the present study demonstrated that the 2-benzhydrylsulfinyl-N-hydroxyacetamide as a new DNA-mediated antimicrobial agent. 2-benzhydrylsulfinyl-N-hydroxyacetamide was experimental new agent to breakdown the bacterial cells by permeating the bacterial genetic materials (nucleic acid and cytoplasmic membrane, leading to loss of cell-wall integrity, damage of nucleic acid, and increased in the permeability of bacterial cell-wall. The 2-benzhydrylsulfinyl-N-hydroxyacetamide could serve as a novel active antimicrobial agent in biomedical applications.