The Potential of Rambutan Seed Extract to Reduce Risk of Cardiovascular Disease in Diabetes Mellitus Type 2

摘要

This study aimed to find out the potential of ethanol extract in rambutan seed to reduce the risk factors of cardiovascular disease by using animal model on diabetes-type 2 (DM-2). The animals used for this study were 3-4 months old male wistar mice with 20-25 grams weight. The diabetes mellitus induction type 2 to the animal model was performed through the administration of high fat diet for 4 weeks followed by the daily dosage of Streptozotocin (STZ) 40 mg/kgbw and it was repeated for 4 times in the last week of induction. The administration of 70% ethanol extract of Binjai rambutan seed (Naphelium lappaceum L.) was done in Carboxy Methyl Cellulose 0.5% and metformin as positive control. The result indicated that 70% ethanol extract of Binjai rambutan seeds had a significant effect on the atherosclerosis index (p <0,01) and all lipid profile parameters. The Binjai rambutan seed extract at 19.2 mg/kgbw dose was the most effective to decrease the atherosclerosis index, total cholesterol, triglyceride, low density lipoprotein, and malodialdehyde and to increase high density lipoprotein and super oxide dismutase of mice blood serum. It can be concluded that the rambutan seed extract at the dose of 19.2 mg/kgbw had the potential to reduce the risk of cardiovascular diabetes in mice by increasing lipid fraction and decreasing oxidative stress.